PENGARUH PEMBERIAN JUS BUAH NAGA MERAH (Hylocereus polyrhizus) TERHADAP KADAR ASAM URAT TIKUS JANTAN GALUR WISTAR (Rattus norvegicus) HIPERURISEMIA

Abstract

High uric acid levels will cause an increase in uric acid crystals that are shaped like needles, especially in the joints. Increased levels of uric acid lead to hyperuricemia. Red dragon fruit contains antioxidants that can reduce uric acid levels. The purpose of the study was to determine the effect of giving red dragon fruit juice (Hylocereus polyrhizus) on uric acid levels in hyperuricemic male wistar rats. This type of research is true experimental with pre test and post test control group design. The subjects of this study were male wistar rats, divided into a healthy group, a control group, an allopurinol group at a dose of 5.4 g/200kgBW and a treatment group that was given red dragon fruit juice at a dose of 4 g/day, 8 g/day and 12 g/day. day. Normality test using Shapiro Wilk. The data were analyzed by using Paired t-test, followed by One-way Anova and Post hoc. The results showed that red dragon fruit juice could significantly reduce acid levels at all doses (p<0.05). The best dose to reduce uric acid levels is 12 g/day and the dose of allopurinol. Red dragon fruit juice with a dose of 12 g/day and the drug allopurinol gave a comparable effect on reducing uric acid levels. Giving red dragon fruit juice at a dose of 4 g/day, 8 g/day, 12 g/day can reduce uric acid levels in hyperuricemic rats.